![]() variably small vacuolated or multivacuolated lipoblasts.predominantly mature adipocytes of variable shape and size and mild too moderate atypia.Histologically atypical spindle cell/pleomorphic lipomatous tumors feature a wide range of microscopic appearances mostly dependent on the relative amount of adipocytes, lipoblasts, atypical spindle cells and multinucleated pleomorphic cells as well as a variable myxoid and/or collagenous background. Macroscopically atypical spindle cell/pleomorphic lipomatous tumors are characterized by a nodular or multinodular growth pattern and are unencapsulated with ill-defined tumor margins 1. Only occasionally they are seen in visceral locations 1-3. LocationĪtypical spindle cell/pleomorphic lipomatous tumors are usually found in the subcutaneous and deep soft tissues of the limbs and limb-girdle areas and less frequently in the head and neck area, the genital region or the back and trunk. The etiology of atypical spindle cell/pleomorphic lipomatous tumors is unknown 1. PathologyĪtypical spindle cell/pleomorphic lipomatous tumors are characterized by a variable amount of atypical spindle cells adipocytes, lipoblasts and pleomorphic or multinucleated cells found in a fibrous and/or myxoid matrix 1-3. The typical presentation is a slow-growing nodule or mass possibly associated with tenderness 1. Men are slightly more frequently affected than women 1,2. myxoid to collagenous extracellular matrixĪtypical spindle cell/pleomorphic lipomatous tumors are mostly seen in patients above 30 years with a peak incidence in the sixth decade but can generally occur in a wide age range.variable amounts of atypical spindle cells, adipocytes uni or multivacuolated lipoblasts and pleomorphic or multinucleated cells.Diagnostic criteriaĭiagnostic criteria according to the WHO classification of soft tissue and bone tumors (5 th edition) 1: Diagnosing atypical spindle cell/pleomorphic lipomatous tumors is based on typical histological and molecular pathological features.
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